Hyaluronic acid is a potential bright spot for helping lower the side effects (of osteoarthritis). Its effectiveness is due to the many methods of actions it deploys, including lubrication, anti-inflammatory and chondroprotective effects. 2
A retrospective longitudinal study involving knee osteoarthritis patients using medico-administrative databases in France demonstrated the effectiveness of hyaluronic acid injections in delaying total knee replacement (TKR) from +51 to +217 days at 1 and 7.5 years, respectively.3
A retrospective longitudinal study involving knee osteoarthritis patients3
Kaplan-Meier curves of time without TKR for HA and non-HA groups.
HA group: patients who received at least one IA HA injection during their follow-up period, non-HA group: patients who received only CS as IA injections, TKR: total knee replacement, IA: intra-articular, HA: hyaluronic acid, CS: corticosteroids.